Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide.
نویسندگان
چکیده
The inhibition of ribonuclease Bi by 3'-N-hydroxyurea-3'-deoxythymidine 5'-phosphate is enhanced by 30-fold in the presence of Zn(2+). Thus, an N-hydroxyurea nucleotide can recruit Zn(2+) to inhibit the enzymatic activity of a ribonuclease. This result engenders a general strategy for the inhibition of non-metalloenzymes by metal complexes.
منابع مشابه
Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 13 3 شماره
صفحات -
تاریخ انتشار 2003